The Science of PlayOn®
Relief When You Need It
From strains to sprains, PlayOn® is here to get back to doing what you love. Use PlayOn® for:
- Post-Workout Soreness
- Muscle Strains
- Bruises and Swelling
- Joint Pain
Experience Relief That’s Faster, Longer, and More Powerful
Say goodbye to pain with PlayOn®, the ultimate topical pain relief solution powered by the patented DuraCool® delivery system. PlayOn® delivers powerful active ingredients quickly and effectively, providing unmatched relief and recovery.
Spray and Watch the Magic Work
Rapid Absorption
Prolonged Action
Dual Sensation
Proven Active Ingredients
Arnica: Highly concentrated Arnica tincture naturally fights inflammation and heals bruises.
- Reduces bruise visibility by up to 50% within 7 days [6].
- Decreases pain severity and swelling post-surgery or trauma [7, 8].
- Inhibits NF-κB, which significantly prevents production of pro-inflammatory molecules [3, 4].
Camphor: Warming Camphor works by activating heat-sensitive receptors.
- Decreases inflammation markers (IL-1β, IL-6, TNF-α) by up to 70% [2].
- Increases local blood flow to tissues by 30-50% [9].
- Boosts collagen and elastin production to promote wound healing [10].
- Camphor with menthol reduced pain scores by 58% and improved foot function by 45% in patients with Plantar Fasciitis [5].
Menthol: Cooling Menthol causes penetrating cooling and warming sensations in the skin.
- Provides rapid pain relief and enhanced muscle recovery [11].
- 65% smaller reduction in power output loss during training when using [11].
- Induces cold and warm sensations while improving circulation [9].
1. Trifecta Therapeutics. Internal Product Efficacy Testing Data. 2025.
2. Lee HJ, Hyun EA, Yoon WJ, Kim BH, Rhee MH, Kang HK, et al. In vitro anti-inflammatory and anti- oxidative effects of Cinnamomum camphora extracts. J Ethnopharmacol. 2006;103(2):208-16. https://doi.org/10.1016/j.jep.2005.08.009.
3. Lyss G, Knorre A, Schmidt TJ, Pahl HL, Merfort I. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem. 1998;273(50):33508-16. https://doi.org/10.1074/jbc.273.50.33508.
4. Lyss G, Schmidt TJ, Merfort I, Pahl HL. Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB. Biol Chem. 1997;378(9):951-61. https://doi.org/10.1515/bchm.1997.378.9.951.
5. Burke BE, Baillie JE. Randomized placebo controlled trial of phytoterpenes in DMSO for the treatment of plantar fasciitis. Scientific Reports. 2024;14(1). https://doi.org/10.1038/s41598-024-65979-1.
6. Leu S, Havey J, White LE, Martin N, Yoo SS, Rademaker AW, et al. Accelerated resolution of laser- induced bruising with topical 20% arnica: a rater-blinded randomized controlled trial. Br J Dermatol. 2010;163(3):557-63. https://doi.org/10.1111/j.1365-2133.2010.09813.x.
7. Iannitti T, Morales-Medina JC, Bellavite P, Rottigni V, Palmieri B. Effectiveness and Safety of Arnica montana in Post-Surgical Setting, Pain and Inflammation. Am J Ther. 2016;23(1):e184-97. https://doi.org/10.1097/mjt.0000000000000036.
8. Brito N, Knipschild P, Doreste-Alonso J. Systematic Review on the Efficacy of Topical Arnica montana for the Treatment of Pain, Swelling and Bruises. Journal of Musculoskeletal Pain. 2014;22(2):216--23. https://doi.org/10.3109/10582452.2014.883012.
9. Kotaka T, Kimura S, Kashiwayanagi M, Iwamoto J. Camphor Induces Cold and Warm Sensations with Increases in Skin and Muscle Blood Flow in Human. Biological and Pharmaceutical Bulletin. 2014;37(12):1913-8. https://doi.org/10.1248/bpb.b14-00442.
10. Fazmiya MJA, Sultana A, Rahman K, Heyat MBB, Sumbul, Akhtar F, et al. Current Insights on Bioactive Molecules, Antioxidant, Anti-Inflammatory, and Other Pharmacological Activities of Cinnamomum camphora Linn. Oxidative Medicine and Cellular Longevity. 2022;2022:1-23.
https://doi.org/10.1155/2022/9354555.
11. Gillis DJ, Vellante A, Gallo JA, D'Amico AP. Influence of Menthol on Recovery From Exercise- Induced Muscle Damage. J Strength Cond Res. 2020;34(2):451-62. https://doi.org/10.1519/jsc.0000000000002833.
DuraCool® Technology
PlayOn® is the first ever pain relief solution powered by DuraCool® time-release sweat-resistant technology!
DuraCool® has been shown to alleviate pain longer and more powerfully by delivering the ingredients deeper into your muscles and joints beyond the skin-cell barrier. This means you will get instantaneous, sustained, and deep relief.
Backed by 10+ years of rigorous scientific research, DuraCool® is a powerful, FDA-compliant, and long-lasting solution for topical pain relief.
Science Backed By Clinical Results
Pain Relief in Gym Injuries
In a 14-day blinded study, PlayOn® demonstrated a significant reduction in pain 60 minutes post-treatment compared to placebo (p=0.041).
Dr. Alex Battaglia, MD, PhD
Having experienced horrendous athlete’s foot and back pain for years, Dr. Battaglia failed traditional therapies. Being a surgeon, inventor and researcher, he invented DuraCool® technology. Duracool® technology is a medication delivery method that has undergone 10+ years of research, including pre-clinical and clinical trials. It has received 40+ worldwide patents and is FDA-compliant. Its cytoprotective qualities have been studied and described on a molecular level in the following publication: PMC5694425.
